APC Mouse Anti-Mouse NK1.1 Antibody (S-R480)

產(chǎn)品型號(hào)：S0B5502

更新時(shí)間：2025-06-30

廠商性質(zhì)：生產(chǎn)廠家

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產(chǎn)品介紹

NK1.1, also known as KLRB1C and NKRP1C, is a type II integral membrane glycoprotein with a C-type lectin domain and belongs to the NKR-P1 family of cell surface receptors. It is expressed as a disulfide-linked homodimer on all NK and NKT cells in some strains of mice, particularly serving as a good marker for these cell types in the C57BL/6 genetic background. NK1.1 associates with the ITAM-bearing γ-chain adaptor molecule and does not engage ligands with an MHC class-I-like fold, but interacts with C-type lectin-like CLEC2 glycoproteins. Although crosslinking of the NK1.1 receptor using a specific mAb can induce NK cell-mediated cytotoxicity and effector cytokine secretion, the in vivo functions of NK1.1 and the identity of its ligand（s） are still not fully understood.

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